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KMID : 1195620210140010108
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Clinical and Experimental Otorhinolaryngology
2021 Volume.14 No. 1 p.108 ~ p.115
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Comprehensive Analysis of Clinicopathologic Factors Predictive of an Unfavorable Prognosis in Patients With Acinic Cell Carcinoma of the Parotid Gland
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Park Young-Min
Yoon Sun-Och
Kim Joo-Hyun
Kang Min-Seok
Kim Da-Hee
Koh Yoon-Woo
Kim Se-Heon
Lim Jae-Yol
Choi Eun-Chang
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Abstract
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Objectives: In subset of patients, acinic cell carcinoma (AcCC) exhibits aggressive features such as recurrence, distant metastasis, and mortality. This study aimed to investigate clinicopathologic factors influencing patients’ prognosis and to identify adverse features predictive of an unfavorable prognosis.
Methods: Between January 2000 and December 2016, 59 patients with AcCC were enrolled in this study.
Results: The patients’ 5-year overall survival rate was 93.3%, and their 5-year recurrence-free survival rate was 80.5%. During the study period, recurrence occurred in 10 patients. The mean time to recurrence after surgery was 26 months (range, 5?60 months). During the study period, three patients died from the disease. Univariate analysis showed that sex, surgical extent, extranodal extension, T classification, and TNM stage were significantly associated with disease recurrence. Multivariate analysis showed that, among the clinicopathologic factors included in the analysis, only TNM stage displayed a statistically significant correlation with disease recurrence.
Conclusion: Surgical treatment alone yielded good results for AcCC, and additional treatment did not affect the recurrence-free survival rate or the overall survival rate, even when the resection margin was less than 1 mm. Other pathologic factors did not show prognostic significance for disease recurrence or death.
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KEYWORD
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Acinic Cell Carcinoma, Parotid Gland, Prognostic Factor
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